As a leading supplier in the field of microarrays, Creative Proteomics is committed to designing and developing various effective biological microarray products for non-clinical research and providing corresponding testing services. Our microarray test platform provides a full range of microarray-based heat shock proteins analysis and determination services to help our global customers conduct relevant research and reduce research costs. We are confident to provide you with high-quality products and high-quality services to help scientific research.
Heat Shock Protein Expression Research
Heat shock protein (HSP) is a highly conserved molecular chaperone that exists in all living cells and is involved in a variety of physiological processes related to development, differentiation, survival, aging and death. After oxidation and other forms of stress, HSP usually increases. At the cellular level, they participate in protein homeostasis, thereby preventing protein denaturation and unfolding under normal and stress conditions (such as high temperature, low oxygen, heavy metals, chemical reagents and anti-tumor drugs). On the other hand, heat shock proteins are usually overexpressed in tumor cells, and they are called "tumorogenesis chaperones" because they promote tumor cell proliferation and inhibit apoptosis. HSPs are a common condition in cells (including under stress conditions including carcinogenesis). They all act as molecular chaperones and inhibitors of apoptosis. Therefore, the role of HSPs in tumors is gradually being emphasized. The heat shock protein antibody microarray can be used for high-throughput analysis of heat shock protein expression, while the heat shock protein printed microarray can be used to screen inhibitors or detect heat shock antibody expression.
Fig 1. Scheme of protein microarray design. (Shi L, et al. 2016)
Service Process
For heat shock protein analysis services, we provide two types of microarray services, one is antibody microarray, which can quantitatively analyze heat shock proteins in biological samples. Our human heat shock protein antibody microarray can detect 9 targets, and compatible sample types include cell culture supernatant, cell lysate, plasma, serum, and tissue lysate. The other is a printed heat shock protein microarray, which can be used for protein interaction analysis, heat shock antibody or heat shock protein inhibitor screening. The use of heat shock protein microarrays for related antibody research is convenient for development and application. Based on the importance of HSPs in diseases such as cancer, Alzheimer's disease or malaria, inhibitors of these molecular chaperones are needed, and heat shock protein microarrays facilitate the development and testing of inhibitors.
Fig 2. Heat shock protein printing microarray service process.
Our Benefits
- Diversified service content and application scenarios
- Strong technical platform and experienced experimental team
- Compare the profiles of different groups of samples to identify potential biomarkers
Creative Proteomics provides high-quality microarray tools and convenient detection services for the development of research related to heat shock proteins. We have a large and well-equipped team of scientists who are committed to cooperating with researchers from all over the world. By choosing outsourcing testing services, your advantage is that you do not need to consider any other expenses, such as equipment, laboratory space, supervision or management. This convenient method can quickly turn around and provide reliable results, thus saving valuable time and resources. Please contact us for more detailed information.
References
- Shi L, Gehin T, Chevolot Y, et al. Anti-heat shock protein autoantibody profiling in breast cancer using customized protein microarray[J]. Analytical and bioanalytical chemistry, 2016, 408(5): 1497-1506.
- Schax E, Walter J G, Märzhäuser H, et al. Microarray-based screening of heat shock protein inhibitors[J]. Journal of biotechnology, 2014, 180: 1-9.
- Schax E, Neunaber J, Stahl F, et al. Multiplexed heat shock protein microarray as a screening platform for the selection of novel drug compounds[J]. Biodiscovery (2014), Nr. 14, 2014.
For research use only, not intended for any clinical use.
